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Biotransformation Chemist Internship
Company: Hypha Discovery Limited
Placement title: Chemist - Biocatalysis - Royal Society of Chemistry internship Length of placement: 3 months, full time Location: Milton Science Park, Abingdon, OX14 4SD Working hours: 08:30-17:00 Monday-Friday Start date: September 2020 (there is some flexibility in the start date) Salary and holiday allowance: £16,000 pro rata (£4,000 for the 3-month internship)
In this lab-based role, the intern will spend time on a research project to further exemplify the use of Hypha’s new enzyme reagents to synthesise conjugated drug metabolites. The intern will gain experience in biocatalysis together with analytical chemistry and purification techniques, and the use of a range of chromatography equipment. This internship is funded by the Royal Society of Chemistry Internship Grant Scheme.
Job description and duties
Identify and source suitable and cost-effective substrate compounds for exemplification
Conduct enzyme reactions with substrates using recombinant glucuronidating and glycosylating enzymes created in house by Hypha’ molecular biology and biochemistry team
Extract reactions and analyse for products of interest by UPLC-MS
Optimise and scale-up reactions to purify and confirm the identity of the products
Record and present the findings of these studies at internal meetings
Adhere to company Health and Safety policies and lab procedures.
Full training will be provided in standard operating procedures, lab safety and executing and analysing experiments.
For more information and how to apply please refer to the additional information provided in the attachment.